Meaning
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Guru is Brahma( who plants the qualities of goodness)
Guru is Vishnu ( who nurtures and fosters the qualities of goodness)
Guru is Maheshwar (who weeds out the bad qualities)
Guru is supereme Brahman itself
Prostration unto that Guru.
Meaning
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Salutations to the Universal teacher, Shree Dakshinamoorthy, who is the repository of all knowledge and who cures the disease of Samsara.